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Does zofran make you sleepy4/30/2023 ![]() Ondansetron is one of several antiemetic drugs used during the vomiting phase of cyclic vomiting syndrome. It is not known if ondansetron is excreted in breast milk. Ondansetron is in pregnancy category B in the US. There appears to be a low risk of harm to the baby with use during pregnancy, though there may be an increase in heart problems among the babies. It is typically used after other antinausea drugs have failed. Ondansetron is used off-label to treat morning sickness and hyperemesis gravidarum of pregnancy. It is more effective than metoclopramide, and less sedating than cyclizine or droperidol. The 5-HT 3 receptor antagonists are the primary medications used to treat and prevent chemotherapy-induced nausea and vomiting and radiotherapy-induced nausea and vomiting.Ī number of medications including ondansetron appear to be effective in controlling postoperative nausea and vomiting. Medical uses Īlthough an effective antiemetic agent, the high cost of brand-name ondansetron initially limited its use to controlling postoperative nausea and vomiting and chemotherapy-induced nausea and vomiting. In 2020, it was the 83rd most commonly prescribed medication in the United States, with more than 8 million prescriptions. It is on the World Health Organization's List of Essential Medicines. Ondansetron was patented in 1984 and approved for medical use in 1990. It does not have any effect on dopamine receptors or muscarinic receptors. ![]() It is a serotonin 5-HT 3 receptor antagonist. It appears to be safe during pregnancy but has not been well studied in this group. Serious side effects include QT prolongation and severe allergic reaction. ![]() Ĭommon side effects include diarrhea, constipation, headache, sleepiness, and itchiness. It can be given by mouth or by injection into a muscle or into a vein. It is also effective for treating gastroenteritis. ![]() Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. ![]()
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